Day One FixesSolvedHow-toUpdated 2026-11-04
The Binding of Isaac: Rebirth: Guide how to unlock ALL 641 achievements
Short answer
In this guide, you can find ways to achieve something new in the game and unlock it.
Steam Community guide by Mamon.
Translation
The author of this guide does not speak English. However, I did my best to translate everything using a translator and Wiki. I would be very grateful for any help with writing or for support in the form of Steam points. Thank you!
↓ Original ↓
https://steamcommunity.com/sharedfiles/filedetails/?id=3408959992
Introduction
In this guide, you can find ways to achieve something new in the game and unlock it.
If you find a way to have suggestions for improvement, the comments are open.
Characters
Isaac
unlocked by default
UnlockTarget
Boss Rush
Mom's Heart
Satan
Isaac
???
The Lamb
Ultra Greed
Ultra Greedier
Hush
Mega Satan
Delirium
Mother
The Beast
Completion Marks
Magdalene
Have 7 or more Red Heart
containers at one time.
UnlockTarget
Boss Rush
Mom's Heart
Satan
Isaac
???
The Lamb
Ultra Greed
Ultra Greedier
Hush
Mega Satan
Delirium
Mother
The Beast
Completion Marks
Cain
Hold 55 Coins at one time
UnlockTarget
Boss Rush
Mom's Heart
Satan
Isaac
???
The Lamb
Ultra Greed
Ultra Greedier
Hush
Mega Satan
Delirium
Mother
The Beast
Completion Marks
Judas
Defeat Satan
UnlockTarget
Boss Rush
Mom's Heart
Satan
Isaac
???
The Lamb
Ultra Greed
Ultra Greedier
Hush
Mega Satan
Delirium
Mother
The Beast
Completion Marks
???
Defeat Mom's Heart 10 times
UnlockTarget
Boss Rush
Mom's Heart
Satan
Isaac
???
The Lamb
Ultra Greed
Ultra Greedier
Hush
Mega Satan
Delirium
Mother
The Beast
Completion Marks
Eve
Don't pick up any Hearts for 2 floors in a row
UnlockTarget
Boss Rush
Mom's Heart
Satan
Isaac
???
The Lamb
Ultra Greed
Ultra Greedier
Hush
Mega Satan
Delirium
Mother
The Beast
Completion Marks
Characters
Samson
Complete 2 floors in a row without taking damage
UnlockTarget
Boss Rush
Mom's Heart
Satan
Isaac
???
The Lamb
Ultra Greed
Ultra Greedier
Hush
Mega Satan
Delirium
Mother
The Beast
Completion Marks
Lazarus
Have 4 or more Soul Hearts at one time
UnlockTarget
Boss Rush
Mom's Heart
Satan
Isaac
???
The Lamb
Ultra Greed
Ultra Greedier
Hush
Mega Satan
Delirium
Mother
The Beast
Completion Marks
Azazel
Make 3 Deals with the Devil in one run
UnlockTarget
Boss Rush
Mom's Heart
Satan
Isaac
???
The Lamb
Ultra Greed
Ultra Greedier
Hush
Mega Satan
Delirium
Mother
The Beast
Completion Marks
Eden
Complete Chapter 4
UnlockTarget
Boss Rush
Mom's Heart
Satan
Isaac
???
The Lamb
Ultra Greed
Ultra Greedier
Hush
Mega Satan
Delirium
Mother
The Beast
Completion Marks
The Lost
Die in a Sacrifice Room while holding Missing Poster
UnlockTarget
Boss Rush
Mom's Heart
